@article{ref1,
title="Synthesis of an Oligonucleotide Suicide Substrate for DNA Methyltransferases",
journal="Journal of organic chemistry",
year="1992",
author="MacMillan, A.M. and Chen, L. and Verdine, G.L.",
volume="57",
number="11",
pages="2989-2991",
abstract="The large-scale chemical synthesis of an oligodeoxynucleotide containing 5-fluoro-2′-deoxycytidine (FdC) and its characterization are described. The FdC residue is introduced via the corresponding 4-0-(2,4,6-trimethylphenyl)-2′-deoxyuridine derivative, which undergoes clean conversion to FdC during removal of the oligonucleotide protecting groups with ammonia. A double-stranded oligodeoxynucleotide containing FdC inactivated the DNA methyltransferase enzyme M.Hae Ⅲ by irreversible formation of a covalent protein-DNA complex. © 1992, American Chemical Society. All rights reserved.<p /><p>Language: en</p>",
language="en",
issn="0022-3263",
doi="10.1021/jo00037a006",
url="http://dx.doi.org/10.1021/jo00037a006"
}