@article{ref1,
title="Aberrant integrity of the cortico-limbic-striatal circuit in major depressive disorder with suicidal ideation",
journal="Journal of psychiatric research",
year="2022",
author="Yang, Jun and Palaniyappan, Lena and Xi, Chang and Cheng, Yixin and Fan, Zebin and Chen, Chujun and Zhang, Manqi and Pan, Yunzhi and Tao, Haojuan and Ouyang, Xuan and Yang, Jie and Liu, Zhening",
volume="148",
number="",
pages="277-285",
abstract="BACKGROUND: Suicidal ideation is a common symptom of major depressive disorder (MDD) that reflects a cognitive alteration in the background of intense emotional dysregulation. Amygdala is a critical emotion processing center that facilitates moving from emotional appraisal to action. However, whether MDD patients with suicidal ideation show dysconnectivity of the amygdala within a large-scale neurocognitive circuitry remains unknown. METHODS: Participants were 22 MDD patients without suicidal ideation (MDD-NSI), 59 MDD patients with suicidal ideation (MDD-SI), and 60 healthy controls (HCs). We compared the amygdala-based resting-state functional connectivity of four amygdala subregions across the three groups. We selected brain regions with significant between-group differences in amygdalar conectivity as the regions of interest (ROI) and performed ROI-to-ROI and graph-theoretical analyses to explore dysconnectivity patterns at various granularity levels. RESULTS: Brain regions showing omnibus differences across the three groups were distributed across a cortico-limbic-striatal circuitry. MDD-SI had unique dysconnectivity of the lateral amygdala with caudate, middle temporal gyrus, and postcentral gyrus compared with the other two groups. MDD-SI and MDD-NSI had shared dysconnectivity of the medial amygdala with medial superior frontal gyrus and middle temporal gyrus. Within the derived cortico-limbic-striatal circuitry, MDD-SI exhibited lower global connectivity, reduced sigma (small-worldness), but increased lambda (path-length) than HCs. Reduced sigma correlated with increased severity of suicidal ideation. We achieved high classification accuracy (84.09%, with AUC 0.82) in distinguishing MDD-SI from MDD-NSI. CONCLUSIONS: Aberrant integrity of the cortico-limbic-striatal circuit centered on the amygdala provides a promising neural substrate for suicidal ideation that requires further investigation in MDD.<p /><p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2022.02.003",
url="http://dx.doi.org/10.1016/j.jpsychires.2022.02.003"
}