@article{ref1,
title="Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium",
journal="Molecular psychiatry",
year="2022",
author="van Velzen, Laura S. and Dauvermann, Maria R. and Colic, Lejla and Villa, Luca M. and Savage, Hannah S. and Toenders, Yara J. and Zhu, Alyssa H. and Bright, Joanna K. and Campos, Adrian I. and Salminen, Lauren E. and Ambrogi, Sonia and Ayesa-Arriola, Rosa and Banaj, Nerisa and Başgöze, Zeynep and Bauer, Jochen and Blair, Karina and Blair, Robert James and Brosch, Katharina and Cheng, Yuqi and Colle, Romain and Connolly, Colm G. and Corruble, Emmanuelle and Couvy-Duchesne, Baptiste and Crespo-Facorro, Benedicto and Cullen, Kathryn R. and Dannlowski, Udo and Davey, Christopher G. and Dohm, Katharina and Fullerton, Janice M. and Gonul, Ali Saffet and Gotlib, Ian H. and Grotegerd, Dominik and Hahn, Tim and Harrison, Ben J. and He, Mengxin and Hickie, Ian B. and Ho, Tiffany C. and Iorfino, Frank and Jansen, Andreas and Jollant, Fabrice and Kircher, Tilo and Klimes-Dougan, Bonnie and Klug, Melissa and Leehr, Elisabeth J. and Lippard, Elizabeth T. C. and McLaughlin, Katie A. and Meinert, Susanne and Miller, Adam Bryant and Mitchell, Philip B. and Mwangi, Benson and Nenadic, Igor and Ojha, Amar and Overs, Bronwyn J. and Pfarr, Julia-Katharina and Piras, Fabrizio and Ringwald, Kai G. and Roberts, Gloria and Romer, Georg and Sanches, Marsal and Sheridan, Margaret A. and Soares, Jair C. and Spalletta, Gianfranco and Stein, Frederike and Teresi, Giana I. and Tordesillas-Gutierrez, Diana and Uyar-Demir, Aslihan and van der Wee, Nic J. A. and van der Werff, Steven J. and Vermeiren, Robert R. J. M. and Winter, Alexandra and Wu, Mon-Ju and Yang, Tony T. and Thompson, Paul M. and Renteria, Miguel E. and Jahanshad, Neda and Blumberg, Hilary P. and van Harmelen, Anne-Laura and Schmaal, Lianne",
volume="27",
number="11",
pages="4550-4560",
abstract="Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen's d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.<p /><p>Language: en</p>",
language="en",
issn="1359-4184",
doi="10.1038/s41380-022-01734-0",
url="http://dx.doi.org/10.1038/s41380-022-01734-0"
}