@article{ref1,
title="Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature",
journal="Arq. bras. neurocir",
year="2019",
author="Julião, Ícaro Elias Gualberto Santos and Santana, Diego Ferreira and Silva, Ledismar José da",
volume="38",
number="3",
pages="183-198",
abstract="Depression is the leading cause of disability worldwide, and it is related to high suicide rates. Furthermore, a great number of patients do not respond to any of the available treatments. Deep brain stimulation (DBS), a versatile technology with expanding indications, is considered a potential treatment for resistant depression. However, in over 10 years of clinical research, its efficacy has not been completely proven. Although new trials using DBS for treatment-resistant depression keep emerging, two of the three Level I evidence-based studies recently conducted have not provided conclusive data. <br><br>METHODological limitations andmajor biases have compromised the obtention of clearer results. In this systematic review of the literature, we intend to critically assess the clinical trials performed in this field.<p /><p>Language: en</p>",
language="en",
issn="0103-5355",
doi="10.1055/s-0039-1692158",
url="http://dx.doi.org/10.1055/s-0039-1692158"
}