@article{ref1,
title="Therapy of murine gastric cancer by 5-FC/CD suicide gene system combined with HSP-PC tumor vaccine",
journal="China Oncology",
year="1998",
author="Chen, Ping and Chen, Zhilin and Xu, Lichun",
volume="",
number="12",
pages="-",
abstract="PURPOSE:To investigate the antitumor effect of 5-fluorocytosine/cytosine deaminase (5FC/CD) suicide gene system combined with heat shock protein 70 peptide complexes(HSP70-PC) tumor vaccine.<br><br>METHODS:5-FC was administrated intraperitoneally after recombinant adenoviruses carrying E.coli CD gene were injected into murine tumor tissue. At the same time,mice bearing tumor were inoculated s.c. with HSP70-PC. <br><br>RESULTS:The combined therapy led to reduction in tumor growth, and complete tumor regression was observed in 70% of the mice. After the combined therapy, the tumor tissue showed more CD + 4 and CD + 8T cells infiltration, and the murine CTL activities increased significantly. <br><br>CONCLUSIONS:The therapy combining 5-FC/CD system with HSP-PC tumor vaccine is very effective in murine gastric cancer, and has potential for clinical usage.<p /><p>Language: zh</p>",
language="zh",
issn="1007-3639",
doi="",
url="http://dx.doi.org/"
}