@article{ref1,
title="Plasma Apolipoprotein-AIV Downregulated in Patients with Major Depressive Disorder having Suicidal Ideation Compared to those without Suicidal Ideation",
journal="Current Proteomics",
year="2022",
author="Mathew, B. and Srinivasan, K. and Pradeep, J. and Thomas, T. and Mandal, A.K.",
volume="19",
number="3",
pages="226-231",
abstract="BACKGROUND: Identification of a peripheral biological marker might aid in identifying patients at high risk of attempting suicide and might help in effective early intervention. <br><br>OBJECTIVE: In the present study, we extend the findings of our previous multidimensional pro-teomics study by examining the levels of plasma Apolipoprotein-AIV in patients diagnosed with major depression with and without suicidal ideation compared to age and gender-matched controls. <br><br>METHODS: Using the mass spectrometry platform, we quantified the levels of plasma Apolipopro-tein-AIV in patients with major depressive disorder with and without suicidal ideation compared to matched controls with isotope-labelled peptides-based quantitative proteomics approach. <br><br>RESULTS: The targeted quantitative proteomics approach with isotope-labelled peptides showed that plasma Apolipoprotein-AIV was significantly downregulated in depressed patients having suicidal ideation 1.45 (CI:1.11-1.90) compared to those without suicidal ideation 0.88 (CI:0.77-1.003). <br><br>CONCLUSION: These findings extend our earlier observation of downregulation of plasma Apolipo-protein-AIV in patients with suicidal attempts to depressed patients with suicidal ideation. The con-sistent downregulation of plasma Apolipoprotein-AIV observed in both the proteomics studies suggests Apolipoprotein-AIV might be a plasma-based biomarker for suicidal behaviour. © 2022 Bentham Science Publishers.<p /><p>Language: en</p>",
language="en",
issn="1570-1646",
doi="10.2174/1570164618666211104151005",
url="http://dx.doi.org/10.2174/1570164618666211104151005"
}