@article{ref1,
title="Selected ion flow tube-mass spectrometry (sift-ms) as an alternative to gas chromatography/mass spectrometry (gc/ms) for the analysis of cyclohexanone and cyclohexanol in plasma",
journal="ACS Omega",
year="2021",
author="Hastie, C. and Thompson, A. and Perkins, M. and Langford, V.S. and Eddleston, M. and Homer, N.Z.M.",
volume="6",
number="48",
pages="32818-32822",
abstract="Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide, with most cases occurring in South Asia and China. Treatment of severe poisoning involves long-term intensive clinical care and is often unsuccessful. Solvent co-formulants (such as cyclohexanone) also contribute to mortality themselves or via more toxic metabolic products (such as cyclohexanol). Faster detection of co-formulants could aid earlier identification of pesticide poisoning and faster intervention, reducing mortality. Conventional analysis of volatiles in blood uses headspace (HS)-GC/MS. This paper evaluates SIFT-MS, a direct MS technique that provides higher sample throughput than GC/MS, as a potential tool for cyclohexanone and cyclohexanol analysis in plasma. Both instruments were calibrated using a conventional approach prior to analysis of each porcine plasma sample on both instruments. Comparative data were evaluated using Bland-Altman plots, demonstrating that the techniques were in good agreement. Compared with GC/MS, SIFT-MS provides fourfold higher sample throughput and shows great promise as an alternative analytical tool. ©<p /><p>Language: en</p>",
language="en",
issn="2470-1343",
doi="10.1021/acsomega.1c03827",
url="http://dx.doi.org/10.1021/acsomega.1c03827"
}