@article{ref1,
title="Massive metformin overdose in two subjects with suicidal behavior: Brief communication",
journal="Turkiye Klinikleri Journal of Medical Sciences",
year="2012",
author="Arikan, S. and Tuzcu, A. and Bahçeci, M. and Kaplan, M.A. and Gökalp, D.",
volume="32",
number="2",
pages="559-562",
abstract="Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure. Only a few cases of deliberate self-poisoning with metformin have been described in the literature. The mechanism of metformin-associated lactic acidosis is complex. In the absence of acute overdose, metformin-associated lactic acidosis rarely develops in patients without comorbidities such as renal or hepatic insufficiency or acute infection. We report two patients who had a large dose of metformin in an attempt to harm themselves and presented with lactic acidosis. In our experience, metformin intoxication may lead a high anion gap metabolic acidosis after a suicide attempt. Sodium bicarbonate infusion is able to correct the acid-base metabolism sufficiently in subjects with normal renal functions. © 2012 by Türkiye Klinikleri.<p /><p>Language: en</p>",
language="en",
issn="1300-0292",
doi="10.5336/medsci.2010-19297",
url="http://dx.doi.org/10.5336/medsci.2010-19297"
}