@article{ref1,
title="Connection re-established: Neurotransmission between the medial prefrontal cortex and serotonergic neurons offers perspectives for fast antidepressant action",
journal="Neuropsychiatry (London)",
year="2011",
author="Etiévant, A. and Lambs-Seas, L. and Abrial, E. and Bétry, C. and Haddjeri, N. and Lucas, G.",
volume="1",
number="2",
pages="165-177",
abstract="The search for fast-acting antidepressants has been a major challenge in neuropsychopharmacology for many years. Although the involvement of serotonin (5-HT) in the mechanisms of action of classical antidepressants has been clearly established, the delayed onset of action of these drugs prompted several authors to propose alternative targets in order to achieve a more rapid relief of symptoms in depressed patients. However, recent studies indicate that it may be possible to elaborate fast-acting antidepressant strategies based on 5-HT, provided that such strategies would directly target 5-HT neuron electrical activity. Furthermore, glutamatergic pyramidal neurons projecting from the medial prefrontal cortex to the dorsal raphé appear to play a critical role. This article presents some of the data that support this hypothesis, including results from medial prefrontal cortex deep-brain stimulation studies, as well as those related to treatments with 5-HT4 agonists and 5-HT7 antagonists. © 2011 Future Medicine Ltd.<p /><p>Language: en</p>",
language="en",
issn="1758-2008",
doi="10.2217/npy.11.9",
url="http://dx.doi.org/10.2217/npy.11.9"
}