@article{ref1,
title="The potential association between isotretinoin treatment, depression and suicidal behaviors: A review",
journal="Current psychiatry reviews",
year="2010",
author="Padgett, C.L.",
volume="6",
number="4",
pages="234-243",
abstract="Since 1982 isotretinoin has been implicated in numerous reports that describe depression, behavioral change and suicidality in patients. Several epidemiological studies have investigated the association suggested by these reports. <br><br>RESULTS have varied. Other research has attempted to establish a plausible biological mechanism associating isotretinoin with these behavioral changes. Current research has focused on the hippocampus. It is possible that individuals that experience these side effects have a predisposition to these outcomes. There is need for additional prospective studies and randomized clinical trials that consider both the presence of a potential mechanism as well as the methodological weaknesses in the current literature. Additional basic science research also needs to further evaluate this potential mechanism. © 2010 Bentham Science Publishers Ltd.<p /><p>Language: en</p>",
language="en",
issn="1573-4005",
doi="10.2174/157340010793499413",
url="http://dx.doi.org/10.2174/157340010793499413"
}