@article{ref1,
title="Protracted deep coma after bromazepam poisoning",
journal="International journal of clinical pharmacology and therapeutics",
year="2010",
author="Lakhal, K. and Pallancher, S. and Mathieu-Daude, J.-c. and Harry, P. and Capdevila, X.",
volume="48",
number="1",
pages="79-83",
abstract="BACKGROUND: Bromazepam intoxication is very common but surprisingly rarely reported. Case description: We describe the case of a 73-year-old woman who suffered from a prolonged coma after acute self poisoning with bromazepam (serum concentration of 2,000 ng/ml at admission, 2 - 10 hours after ingestion of up to 180 mg) and zolpidem (900 ng/ml at admission). Only the former lasted at toxic concentrations. Recovery of consciousness allowed extubation on Day 16. Repeat-dose activated charcoal (25 g every 6 h from Day 14 to 16) resulted in minimal effects on bromazepam grossly estimated kinetics. <br><br>CONCLUSION: Despite its relativel low theoretic half-life, bromazepam may induce a prolonged life-threatening coma, even in the absence of renal or hepatic failure. © 2010 Dustri-Verlag Dr. K. Feistle.<p /><p>Language: en</p>",
language="en",
issn="0946-1965",
doi="10.5414/CPP48079",
url="http://dx.doi.org/10.5414/CPP48079"
}