@article{ref1,
title="Progress in the development of early-onset antidepressants",
journal="Chinese Pharmacological Bulletin",
year="2008",
author="Xue, R. and Zhang, Y.-z. and Zou, L.-b.",
volume="24",
number="12",
pages="1558-1561",
abstract="Existing antidepressants exhibit delayed onset of action, which can decrease the compliance of the patients and enhance the risk of suicide. How to produce early-onset antidepressants with higher efficacy and lower adverse reactions has become a crucial point in the research of antidepressants. It has been demonstrated that selective 5-HT1A antagonist, α2 antagonist and 5-HT2A antagonist can accelerate the response of classic antidepressants. Furthermore,5-HT/NE dual reuptake inhibitor and 5-HT/NE/DA triple reuptake inhibitor can also produce early onset of action. Here several reasons for the delayed onset of action and the progress in the development of early-onset antidepressants are reviewed.<p /><p>Language: zh</p>",
language="zh",
issn="1001-1978",
doi="",
url="http://dx.doi.org/"
}