@article{ref1,
title="Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS, and LC-ESI-MS-MS",
journal="Journal of analytical toxicology",
year="2000",
author="Turcant, A. and Cailleux, A. and Le Bouil, A. and Allain, P. and Harry, P. and Renault, A.",
volume="24",
number="3",
pages="157-164",
abstract="A case of self poisoning with metobromuron, a urea derivative used as a herbicide, is reported. Severe methemoglobinemia observed at the admission (80%) disappeared only at day 11, and hemolysis appeared at day 4 and decreased slowly to day 12. Metobromuron was analyzed by liquid chromatography with diode-array detection. Initial plasma concentration and elimination half-life were 4.9 mg/L and 5 h, respectively. Several metabolites were also detected, and four of those were identified by liquid chromatography-electrospray mass spectrometry. Normetobromuron, bromophenylurea, and bromoacetanilide were detected in plasma, but only N-methyl bromophenylurea was detected in urine. Bromoacetanilide probably results from acetylation of the intermediate bromoaniline. Methemoglobinemia could result from metabolization of metobromuron to bromoaniline and bromoacetanilide.<p /><p>Language: en</p>",
language="en",
issn="0146-4760",
doi="10.1093/jat/24.3.157",
url="http://dx.doi.org/10.1093/jat/24.3.157"
}