@article{ref1,
title="Simultaneous analyses of hypoglycemic agents and C-peptide are essential in a homicide case with the combined dosing insulin and insulin-releasing drug",
journal="Legal medicine (Elsevier)",
year="2002",
author="Uezono, T. and Shiono, H. and Shimizu, K. and Ogawa, K. and Saito, O. and Yoshida, M. and Mizukami, H. and Matsubara, K.",
volume="4",
number="1",
pages="34-36",
abstract="A 5-year-old girl was given a sulfonylurea hypoglycemic agent, 25 mg of glibenclamide (ten tablets of Euglucon) with two benzodiazepine drugs, 2 mg of estazoram and 0.75 mg of triazolam (one tablet of Eurodin and three tablets of Halcion), by her 37-year-old pharmacist father and then injected with 70 units of insulin (NovoLet 40R). She died several hours after the injection of insulin. Autopsy was carried out 12 h after the death. A glibenclamide level of 103 ng/ml was detected in the serum collected from the heart at autopsy. The serum insulin and C-peptide concentrations were 295 μU/ml and 0.5 ng/ml, respectively. The high level of insulin and the low level of C-peptide indicated that most of the serum insulin was exogenous. The determination of the serum C-peptide concentration was useful to the diagnosis of hypoglycemia caused by exogenous insulin even in the case of co-administration with an endogenous-insulin-releasing agent. © 2002 Elsevier Science Ireland Ltd. All rights reserved.<p /><p>Language: en</p>",
language="en",
issn="1344-6223",
doi="10.1016/S1344-6223(01)00042-6",
url="http://dx.doi.org/10.1016/S1344-6223(01)00042-6"
}