@article{ref1,
title="Transitional cell carcinoma expresses high levels of Fas ligand in vivo",
journal="BJU international",
year="1999",
author="Lee, S.H. and Lee, J.Y. and Park, W.S. and Kim, S.y. and Jang, J.J. and Yoo, N.J.",
volume="83",
number="6",
pages="698-702",
abstract="OBJECTIVE. To characterize the Fas-Fas ligand system, a main apoptotic pathway, in transitional cell carcinoma (TCC) of the urinary bladder, by analysing the expression of Fas and Fas ligand (FasL) in TCC samples. <br><br>MATERIALS AND METHODS. Archival paraffin-embedded tissues from 37 patients with TCC were analysed by immunohistochemistry to determine Fas and FasL expression. <br><br>RESULTS. Fas and FasL were detected on the cell surface and cytoplasm of respectively 34 (92%) and all cases analysed. The expression of Fas and FasL did not differ with the cytological grade of TCC. <br><br>CONCLUSION. The high expression of FasL in TCC, reported for the first time in the present study, suggests that FasL may contribute to the immune escape of TCC through killing Fas-bearing lymphocytes. Co-expression of Fas with FasL also suggests that TCC may have pathways resistant to Fas-mediated autocrine cell suicide.<p /><p>Language: en</p>",
language="en",
issn="1464-4096",
doi="10.1046/j.1464-410X.1999.00975.x",
url="http://dx.doi.org/10.1046/j.1464-410X.1999.00975.x"
}