@article{ref1,
title="Suicide and depression: Mechanisms associated with A2A-adrenoceptors",
journal="Médecine et hygiène",
year="1999",
author="Garcia-Sevilla, J.A. and Walzer, C. and La Harpe, R. and Eytan, A. and Guimón, J.",
volume="57",
number="2269",
pages="1744-1749",
abstract="Suicide and depression are associated with an increased density of a2-adrenoceptors in specific regions of the human brain. The function of these inhibitory receptors involves various regulatory proteins (the G inhibitory protein Gail/2 and the GRK2 kinase), which work in concert with the receptors. Increased levels of a2A-adrenoceptors, Gail/2 proteins, and membrane-associated GRK2 were found in the prefrontal cortex of suicide victims and antidepressant-free depressed suicide victims. In these two groups, then were significant correlations between the levels of GRK2 (dependent variable) and those a2A-adrenoceptors and Gail/2 proteins (independent variables). Antemortem antidepressant treatment was associated with a significant reduction in the levels of Gail/2 proteins, but with modest decreases in the levels of a2A-adrenoceptors and GRK2 in the brains of depressed suicide victims. Taken altogether, these results support the existence of supersensitive a2A-adrenoceptors in subjects with major depression.<p /><p>Language: fr</p>",
language="fr",
issn="0025-6749",
doi="",
url="http://dx.doi.org/"
}