@article{ref1,
title="Report of a case of intoxication by flecainide",
journal="Urgences médicales : revue européenne d'oxyologie",
year="1997",
author="Andre, P. and Berginiat, N. and Triaureau, G. and Lalande, G.",
volume="16",
number="5",
pages="205-207",
abstract="Some poisonings with antiarrhythmic drugs still have a poor prognosis, especially in cases of voluntary massive ingestion, despite progress in intensive care facilities and procedures. This case report concerns the suicidal intoxication of a 39-year-old female without any medical history who ingested six grams of flecainide (Vaughan-Williams class lc), probably associated with nadolol (beta-adrenergic blocking agent). Despite rapid intensive care, the outcome was unsuccessful, featuring a cardiac shock without response to drugs and severe cardiac rhythm and conduction problems. Flecainide blood level (1.9 mg/L) showed a toxic concentration, but was uncorrelated with the clinical severity and the ingested dose of six grams. We suggest the associated intoxication with a beta-adrenergic blocking agent may have been an aggravating factor hastening the lethal outcome.<p /><p>Language: fr</p>",
language="fr",
issn="0923-2524",
doi="10.1016/S0923-2524(97)89779-2",
url="http://dx.doi.org/10.1016/S0923-2524(97)89779-2"
}