@article{ref1,
title="Original article: platelet serotonin level and impulsivity in human self-destructive behavior: a biological and psychological study",
journal="Journal of neurosciences in rural practice",
year="2017",
author="Era Dutta, S. and Gupta, S. and Raju, M.S.V.K. and Kumar, A. and Pawar, A.",
volume="8",
number="2",
pages="199-203",
abstract="Context: Suicide is a disease and a global public health problem. Suicidology has come to become a topic of study for intervention and research. The serotonin (5-hydroxytryptamine [5HT]) system has remained a prime area of investigation. The neurons and platelets display structural and functional similarities. Ninety-nine percent of 5HT is contained in platelets, which shares similar 5HT uptake and release mechanisms with 5HT neurons. Aims: This study aims to study human self-destructive behavior (HSDB). <br><br>OBJECTIVES: Exploring the biological (serotonin levels in platelets) and psychological aspects (impulsivity) of attempted suicide or HSDB. Settings and Design: Thirty-one patients, above the age of 18 years, with a recent history of HSDB, were studied and given an International Classification of Diseases-10 diagnosis, after a detailed interview. <br><br>SUBJECTS AND METHODS: For the platelet 5HT estimation, blood samples were collected, and enzyme immunometric assay carried out. Detailed assessment of the impulsivity was done by the 25-item structured diagnostic interview for borderlines by Zanarini et al. Statistical Analysis Used: We obtained both categorical and continuous data. Chi-square test, Fisher's test, Student's t-test, and Pearson's product moment correlation were used. <br><br>RESULTS: Female subjects outnumbered males by 2:1. Major depression, adjustment disorder, personality disorder were predominant diagnoses. The mean platelet serotonin concentration for males = 57.3 ng/ml, that of females = 56.05 ng/ml (P > 0.05). Platelet 5HT levels were found to be negatively correlated with impulsivity scores (P < 0.05). <br><br>CONCLUSIONS: Platelet serotonin levels in our study sample were quite low when compared with those reported in published literature. Low serotonin levels were inversely related to impulsivity, but only in males. © 2017 Journal of Neurosciences in Rural Practice | Published by Wolters Kluwer - Medknow.<p /><p>Language: en</p>",
language="en",
issn="0976-3147",
doi="10.4103/jnrp.jnrp_425_16",
url="http://dx.doi.org/10.4103/jnrp.jnrp_425_16"
}