@article{ref1,
title="Distinct effects of first-episode and recurrent major depression disorder on brain changes related to suicidal ideation: evidence from the REST-meta-MDD Project",
journal="Journal of affective disorders",
year="2024",
author="Sun, Fenfen and Yan, Jin and Pang, Jianan and Song, Mingqiao and Wang, Minmin and Huang, Tianming and Zhao, Zhiyong",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Significant differences in clinical manifestations between first-episode and recurrent major depression disorder (FE-MDD/R-MDD) have been demonstrated in previous studies, including the degree of suicide attempt. However, the potential brain mechanism underlying the effect of depressive episode frequency on suicidal ideation (SI) remains unclear. <br><br>METHODS: In this study, 102 patients with FE-MDD (SI/non-SI: N = 70/32) and 71 matched normal controls (NCs), as well as 75 patients with R-MDD (SI/non-SI: N = 37/38) and 49 matched NCs were screened from the Chinese REST-meta-MDD consortium. T1-weighted and resting-state fMRI images were used to calculate gray matter volume (GMV) and fractional amplitude of low-frequency fluctuations (fALFF), respectively. <br><br>RESULTS: Group comparisons revealed that FE-MDD showed changes only in GMV, while R-MDD showed changes in both GMV and fALFF compared to NCs. SI-specific GMV decreases were observed in the right cerebellum, superior marginal gyrus, and left middle temporal gyrus in FE-MDD patients, while SI-specific fALFF decreases were observed in bilateral superior frontal gyrus and increases in bilateral cerebellum and left parahippocampal gyrus in R-MDD patients. Moreover, a negative correlation was found between GMV value in right cerebellum and HAMD score. <br><br>CONCLUSIONS: These findings suggest that first-episode and recurrent MDD show different effects on brain structure and function in patients with SI, providing a potential explanation for the distinct clinical manifestations of MDD patients from a brain mechanisms perspective.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2024.01.213",
url="http://dx.doi.org/10.1016/j.jad.2024.01.213"
}