@article{ref1,
title="Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors",
journal="Molecular psychiatry",
year="2023",
author="Ben-Zion, Z. and Korem, N. and Spiller, T.R. and Duek, O. and Keynan, J.N. and Admon, R. and Harpaz-Rotem, I. and Liberzon, I. and Shalev, A.Y. and Hendler, T.",
volume="28",
number="2",
pages="657-667",
abstract="The hippocampus and the amygdala play a central role in post-traumatic stress disorder (PTSD) pathogenesis. While alternations in volumes of both regions have been consistently observed in individuals with PTSD, it remains unknown whether these reflect pre-trauma vulnerability traits or acquired post-trauma consequences of the disorder. Here, we conducted a longitudinal panel study of adult civilian trauma survivors admitted to a general hospital emergency department (ED). One hundred eligible participants (mean age = 32.97 ± 10.97, n = 56 females) completed both clinical interviews and structural MRI scans at 1-, 6-, and 14-months after ED admission (alias T1, T2, and T3). While all participants met PTSD diagnosis at T1, only n = 29 still met PTSD diagnosis at T3 (a &quot;non-Remission&quot; Group), while n = 71 did not (a &quot;Remission&quot; Group). Bayesian multilevel modeling analysis showed robust evidence for smaller right hippocampus volume (P+ of ~0.014) and moderate evidence for larger left amygdala volume (P+ of ~0.870) at T1 in the &quot;non-Remission&quot; group, compared to the &quot;Remission&quot; group. Subregion analysis further demonstrated robust evidence for smaller volume in the subiculum and right CA1 hippocampal subregions (P+ of ~0.021-0.046) in the &quot;non-Remission&quot; group. No time-dependent volumetric changes (T1 to T2 to T3) were observed across all participants or between groups. <br><br>RESULTS support the &quot;vulnerability trait&quot; hypothesis, suggesting that lower initial volumes of specific hippocampus subregions are associated with non-remitting PTSD. The stable volume of all hippocampal and amygdala subregions does not support the idea of consequential, progressive, stress-related atrophy during the first critical year following trauma exposure. <p /> <p>Language: en</p>",
language="en",
issn="1359-4184",
doi="10.1038/s41380-022-01842-x",
url="http://dx.doi.org/10.1038/s41380-022-01842-x"
}