@article{ref1,
title="Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study",
journal="Psychological medicine",
year="2023",
author="Trotta, Giulia and Rodríguez, Victoria and Quattrone, Diego and Spinazzola, Edoardo and Tripoli, Giada and Gayer-Anderson, Charlotte and Freeman, Tom P. and Jongsma, Hannah E. and Sideli, Lucia and Aas, Monica and Stilo, Simona A. and La Cascia, Caterina and Ferraro, Laura and La Barbera, Daniele and Lasalvia, Antonio and Tosato, Sarah and Tarricone, Ilaria and D'Andrea, Giuseppe and Tortelli, Andrea and Schürhoff, Franck and Szöke, Andrei and Pignon, Baptiste and Selten, Jean-Paul and Velthorst, Eva and de Haan, Lieuwe and Llorca, Pierre-Michel and Rossi Menezes, Paulo and Del Ben, Cristina M. and Santos, Jose Luis and Arrojo, Manuel and Bobes, Julio and Sanjuan, Julio and Bernardo, Miquel and Arango, Celso and Kirkbride, James B. and Jones, Peter B. and Richards, Alexander and Rutten, Bart P. and van Os, Jim and Austin-Zimmerman, Isabelle and Li, Zhikun and Morgan, Craig and Sham, Pak C. and Vassos, Evangelos and Wong, Chloe and Bentall, Richard and Fisher, Helen L. and Murray, Robin M. and Alameda, Luis and Di Forti, Marta",
volume="53",
number="15",
pages="7375-7384",
abstract="BACKGROUND: Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. <br><br>METHODS: Data were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. <br><br>RESULTS: The association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. <br><br>CONCLUSIONS: Harmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.<p /> <p>Language: en</p>",
language="en",
issn="0033-2917",
doi="10.1017/S0033291723000995",
url="http://dx.doi.org/10.1017/S0033291723000995"
}