@article{ref1,
title="A comprehensive characterization of cognitive performance, clinical symptoms, and cortical activity following mild traumatic brain injury (mTBI)",
journal="Applied neuropsychology. Adult",
year="2023",
author="Coyle, Hannah L. and Bailey, Neil W. and Ponsford, Jennie and Hoy, Kate E.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: The objective of this study was to investigate clinical symptoms, cognitive performance and cortical activity following mild traumatic brain injury (mTBI). <br><br>METHODS: We recruited 30 individuals in the sub-acute phase post mTBI and 28 healthy controls with no history of head injury and compared these groups on clinical, cognitive and cortical activity measures. Measures of cortical activity included; resting state electroencephalography (EEG), task related EEG and combined transcranial magnetic stimulation with electroencephalography (TMS-EEG). Primary analyses investigated clinical, cognitive and cortical activity differences between groups. Exploratory analyses investigated the relationships between these measures. <br><br>RESULTS: At 4 weeks' post injury, mTBI participants exhibited significantly greater post concussive and clinical symptoms compared to controls; as well as reduced cognitive performance on verbal learning and working memory measures. mTBI participants demonstrated alterations in cortical activity while at rest and in response to stimulation with TMS. <br><br>CONCLUSIONS: The present study comprehensively characterized the multidimensional effect of mTBI in the sub-acute phase post injury, showing a broad range of differences compared to non-mTBI participants. Further research is needed to explore the relationship between these pathophysiologies and clinical/cognitive symptoms in mTBI.<p /> <p>Language: en</p>",
language="en",
issn="2327-9095",
doi="10.1080/23279095.2023.2286493",
url="http://dx.doi.org/10.1080/23279095.2023.2286493"
}