@article{ref1,
title="Potential risk of driving performance under combined conditions of taking second-generation antihistamines and attending calls using a hands-free function",
journal="Traffic injury prevention",
year="2023",
author="Sagara, Atsunobu and Nagahama, Akihito and Aki, Hayato and Yoshimura, Hiroki and Hiraide, Makoto and Shimizu, Takatsune and Sano, Motohiko and Yumoto, Tetsuro and Hosoe, Tomoo and Tanaka, Kenji",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: Although second-generation antihistamines have reduced sedation-related side effects compared to first-generation antihistamines, sedation may still impair motor vehicle driving performance. Moreover, receiving/making phone calls using a hands-free function can negatively affect driving performance. Therefore, herein, driving performance was evaluated using a driving simulator to gain insights into the hazards of driving by combining second-generation antihistamines and a calling task, i.e., simulated calls using a hands-free function. <br><br>METHODS: In this study, 20 subjects drove in a driving simulator in the absence or presence of a calling task while taking or not taking second-generation antihistamines. Driving performances for nonemergency and emergency events were determined, and a comparative analysis of intra-individual variability when taking and not taking second-generation antihistamines was conducted. <br><br>RESULTS: First, when nonemergency and emergency were examined in the absence of a calling task, no significant difference in driving performance was observed between taking and not taking second-generation antihistamines. Next, when the nonemergency event was examined in the presence of a calling task, no significant difference in driving performance was observed between taking and not taking second-generation antihistamines. However, when the emergency event was examined in the presence of a calling task, a significant difference in driving performance was observed between taking and not taking second-generation antihistamines, thus resulting in reduced driving performance. <br><br>CONCLUSIONS: The new system with added calling tasks allowed the extraction of the potential risks of driving performance of second-generation antihistamines that may have been previously overlooked. This study suggests that pharmacists and other healthcare professionals may need to instruct people taking any second-generation antihistamine to focus on driving and not on subtasks that require cognitive load such as talking while driving.  Keywords: Drug impaired driving <p /> <p>Language: en</p>",
language="en",
issn="1538-9588",
doi="10.1080/15389588.2023.2265002",
url="http://dx.doi.org/10.1080/15389588.2023.2265002"
}