@article{ref1,
title="Prelimbic area to lateral hypothalamus circuit drives social aggression",
journal="iScience",
year="2023",
author="Bai, Fuhai and Huang, Lu and Deng, Jiao and Long, Zonghong and Hao, Xianglin and Chen, Penghui and Wu, Guangyan and Wen, Huizhong and Deng, Qiangting and Bao, Xiaohang and Huang, Jing and Yang, Ming and Li, Defeng and Ren, Yukun and Zhang, Min and Xiong, Ying and Li, Hong",
volume="26",
number="10",
pages="e107718-e107718",
abstract="Controlling aggression is a vital skill in social species such as rodents and humans and has been associated with the medial prefrontal cortex (mPFC). In this study, we showed that during aggressive behavior, the activity of GABAergic neurons in the prelimbic area (PL) of the mPFC was significantly suppressed. Specific activation of GABAergic PL neurons significantly curbed male-to-male aggression and inhibited conditioned place preference (CPP) for aggression-paired contexts, whereas specific inhibition of GABAergic PL neurons brought about the opposite effect. Moreover, GABAergic projections from PL neurons to the lateral hypothalamus (LH) orexinergic neurons mediated aggressive behavior. Finally, directly modulated LH-orexinergic neurons influence aggressive behavior. These results suggest that GABAergic PL-orexinergic LH projection is an important control circuit for intermale aggressive behavior, both of which could be targets for curbing aggression.<p /> <p>Language: en</p>",
language="en",
issn="2589-0042",
doi="10.1016/j.isci.2023.107718",
url="http://dx.doi.org/10.1016/j.isci.2023.107718"
}