@article{ref1,
title="Nitrous oxide reduced suicidal ideation in treatment-resistant major depression in exploratory analysis",
journal="Journal of clinical psychiatry",
year="2023",
author="de Leon, Victoria C. and Kumar, Arun and Nagele, Peter and Palanca, Ben J. and Gott, Britt and Janski, Alvin and Zorumski, Charles F. and Conway, Charles R.",
volume="84",
number="5",
pages="22br14725-22br14725",
abstract="<p>Nitrous oxide (N2O) is a colorless, odorless gas commonly used as an anesthetic in dental and obstetric settings.1 Previously, our group demonstrated that N2O has rapid antidepressant effects.2,3 N2O has N-methyl-d-aspartate receptor antagonist properties shared with ketamine; esketamine, an enantiomer, has received FDA approval for rapid reduction in suicidal ideation in major depressive disorder (MDD). In the present analysis, we examined N2O’s ability to reduce suicidal ideation in a pooled secondary analysis of data from 3 crossover trials investigating N2O in subjects with treatment-resistant major depression (TRMD) ...</p> <p>Language: en</p>",
language="en",
issn="0160-6689",
doi="10.4088/JCP.22br14725",
url="http://dx.doi.org/10.4088/JCP.22br14725"
}