@article{ref1,
title="Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits",
journal="Psychological medicine",
year="2023",
author="Otsuka, Ikuo and Galfalvy, Hanga and Guo, Jia and Akiyama, Masato and Rujescu, Dan and Turecki, Gustavo and Hishimoto, Akitoyo and Mann, J. John",
volume="53",
number="6",
pages="2689-2697",
abstract="BACKGROUND: Suicidal behavior is moderately heritable and a consequence of a combination of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders. Here, we sought to examine shared polygenic effects between various psychiatric disorders/traits and suicidal behavior and to compare the shared polygenic effects of various psychiatric disorders/traits on non-fatal suicide attempt and suicide death. <br><br>METHODS: We used our genotyped European ancestry sample of 260 non-fatal suicide attempters, 317 suicide decedents and 874 non-psychiatric controls to test whether polygenic risk scores (PRSs) obtained from large GWASs for 22 suicide-related psychiatric disorders/traits were associated with suicidal behavior. <br><br>RESULTS were compared between non-fatal suicide attempt and suicide death in a sensitivity analysis. <br><br>RESULTS: PRSs for major depressive disorder, bipolar disorder, schizophrenia, ADHD, alcohol dependence, sensitivity to environmental stress and adversity, educational attainment, cognitive performance, and IQ were associated with suicidal behavior (Bonferroni-corrected p < 2.5 × 10(-4)). The polygenic effects of all 22 psychiatric disorders/traits had the same direction (p for binomial tests = 4.8 × 10(-7)) and were correlated (Spearman's ρ = 0.85) between non-fatal suicide attempters and suicide decedents. <br><br>CONCLUSIONS: We found that polygenic effects for major psychiatric disorders and diathesis-related traits including stress responsiveness and intellect/cognitive function contributed to suicidal behavior. While we found comparable polygenic architecture between non-fatal suicide attempters and suicide decedents based on correlations with PRSs of suicide-related psychiatric disorders/traits, our analyses are limited by small sample size resulting in low statistical power to detect difference between non-fatal suicide attempt and suicide death.<p /> <p>Language: en</p>",
language="en",
issn="0033-2917",
doi="10.1017/S0033291721004700",
url="http://dx.doi.org/10.1017/S0033291721004700"
}