@article{ref1,
title="Suicidal ideation and non-suicidal self-injury following early childhood psychotic experiences in preadolescent children at familial high risk of schizophrenia or bipolar disorder-the Danish High Risk and Resilience Study, VIA 11",
journal="Schizophrenia bulletin",
year="2023",
author="Gregersen, Maja and Jepsen, Jens Richardt Møllegaard and Brandt, Julie Marie and Søndergaard, Anne and Rohd, Sinnika Birkehøj and Veddum, Lotte and Knudsen, Christina Bruun and Andreassen, Anna Krogh and Burton, Birgitte Klee and Hjorthøj, Carsten and Krantz, Mette Falkenberg and Greve, Aja Neergaard and Bliksted, Vibeke and Mors, Ole and Nordentoft, Merete and Thorup, Anne Amalie Elgaard and Hemager, Nicoline",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND AND HYPOTHESIS: Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals. STUDY DESIGN: Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11). STUDY RESULTS: Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1-6.9; P =.03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2-7.7; P =.02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1-8.8; P =.03; OR 3.8, 95% CI, 1.3-11.5; P =.02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2-16.7; P =.03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups. <br><br>CONCLUSIONS: Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.<p /> <p>Language: en</p>",
language="en",
issn="0586-7614",
doi="10.1093/schbul/sbad052",
url="http://dx.doi.org/10.1093/schbul/sbad052"
}