@article{ref1,
title="Enhanced putamen functional connectivity underlies altered risky decision-making in age-related cognitive decline",
journal="Scientific reports",
year="2023",
author="Ren, Ping and Hou, Gangqiang and Ma, Manxiu and Zhuang, Yuchuan and Huang, Jiayin and Tan, Meiling and Wu, Donghui and Luo, Guozhi and Zhang, Zhiguo and Rong, Han",
volume="13",
number="1",
pages="e6619-e6619",
abstract="Risky decision-making is critical to survival and development, which has been compromised in elderly populations. However, the neural substrates of altered financial risk-taking behavior in aging are still under-investigated. Here we examined the intrinsic putamen network in modulating risk-taking behaviors of Balloon Analogue Risk Task in healthy young and older adults using resting-state fMRI. Compared with the young group, the elderly group showed significantly different task performance. Based on the task performance, older adults were further subdivided into two subgroups, showing young-like and over-conservative risk behaviors, regardless of cognitive decline. Compared with young adults, the intrinsic pattern of putamen connectivity was significantly different in over-conservative older adults, but not in young-like older adults. Notably, age-effects on risk behaviors were mediated via the putamen functional connectivity. In addition, the putamen gray matter volume showed significantly different relationships with risk behaviors and functional connectivity in over-conservative older adults. Our findings suggest that reward-based risky behaviors might be a sensitive indicator of brain aging, highlighting the critical role of the putamen network in maintaining optimal risky decision-making in age-related cognitive decline.<p /> <p>Language: en</p>",
language="en",
issn="2045-2322",
doi="10.1038/s41598-023-33634-w",
url="http://dx.doi.org/10.1038/s41598-023-33634-w"
}