@article{ref1,
title="Aberrant connectivity in the right amygdala and right middle temporal gyrus before and after a suicide attempt: examining markers of suicide risk",
journal="Journal of affective disorders",
year="2023",
author="Jagger-Rickels, Audreyana and Stumps, Anna and Rothlein, David and Evans, Travis and Lee, Daniel and McGlinchey, Regina and Degutis, Joseph and Esterman, Michael",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Functional neuroimaging has the potential to help identify those at risk for self-injurious thoughts and behaviors, as well as inform neurobiological mechanisms that contribute to suicide. Based on whole-brain patterns of functional connectivity, our previous work identified right amygdala and right middle temporal gyrus (MTG) connectivity patterns that differentiated Veterans with a history of a suicide attempt (SA) from a Veteran control group. In this study, we aimed to replicate and extend our previous findings by examining whether this aberrant connectivity was present prior to and after a SA. In a trauma-exposed Veteran sample (92 % male, mean age = 34), we characterized if the right amygdala and right MTG connectivity differed between a psychiatric control sample (n = 56) and an independent sample of Veterans with a history of SA (n = 17), using fMRI data before and after the SA. The right MTG and amygdala connectivity differed between Veterans with and without a history of SA (replication), while MTG connectivity also distinguished Veterans prior to engaging in a SA (extension). In a second study, we investigated the connectivity in those with current ideation (n = 27) compared to matched psychiatric controls (n = 27); neither of these SA connectivity patterns significantly differed. These results indicate a potential stable marker of suicide risk (right MTG connectivity) as well as a potential marker of acute risk of or recent SA (right amygdala connectivity) that are independent of current ideation.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2023.04.061",
url="http://dx.doi.org/10.1016/j.jad.2023.04.061"
}