@article{ref1,
title="Neurobiological and genetic correlates of the dissociative subtype of posttraumatic stress disorder",
journal="Journal of psychopathology and clinical science",
year="2023",
author="Wolf, Erika J. and Hawn, Sage E. and Sullivan, Danielle R. and Miller, Mark W. and Sanborn, Victoria and Brown, Emma and Neale, Zoe and Fein-Schaffer, Dana and Zhao, Xiang and Logue, Mark W. and Fortier, Catherine B. and McGlinchey, Regina E. and Milberg, William P.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Approximately 10%-30% of individuals with posttraumatic stress disorder (PTSD) exhibit a dissociative subtype of the condition defined by symptoms of depersonalization and derealization. This study examined the psychometric evidence for the dissociative subtype of PTSD in a sample of young, primarily male post-9/11-era Veterans (n = 374 at baseline and n = 163 at follow-up) and evaluated its biological correlates with respect to resting state functional connectivity (default mode network [DMN]; n = 275), brain morphology (hippocampal subfield volume and cortical thickness; n = 280), neurocognitive functioning (n = 337), and genetic variation (n = 193). Multivariate analyses of PTSD and dissociation items suggested a class structure was superior to dimensional and hybrid ones, with 7.5% of the sample comprising the dissociative class; this group showed stability over 1.5 years. Covarying for age, sex, and PTSD severity, linear regression models revealed that derealization/depersonalization severity was associated with: decreased DMN connectivity between bilateral posterior cingulate cortex and right isthmus (p =.015; adjusted-p [p(adj)] =.097); increased bilateral whole hippocampal, hippocampal head, and molecular layer head volume (p =.010-.034; p(adj) =.032-.053); worse self-monitoring (p =.018; p(adj) =.079); and a candidate genetic variant (rs263232) in the adenylyl cyclase 8 gene (p =.026), previously associated with dissociation. <br><br>RESULTS converged on biological structures and systems implicated in sensory integration, the neural representation of spatial awareness, and stress-related spatial learning and memory, suggesting possible mechanisms underlying the dissociative subtype of PTSD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).<p /> <p>Language: en</p>",
language="en",
issn="2769-7541",
doi="10.1037/abn0000795",
url="http://dx.doi.org/10.1037/abn0000795"
}