@article{ref1,
title="The cortical NG2-glia response to traumatic brain injury",
journal="Glia",
year="2023",
author="Dean, Terry and Ghaemmaghami, Javid and Corso, John and Gallo, Vittorio",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Traumatic brain injury (TBI) is a significant worldwide cause of morbidity and mortality. A chronic neurologic disease bearing the moniker of &quot;the silent epidemic,&quot; TBI currently has no targeted therapies to ameliorate cellular loss or enhance functional recovery. Compared with those of astrocytes, microglia, and peripheral immune cells, the functions and mechanisms of NG2-glia following TBI are far less understood, despite NG2-glia comprising the largest population of regenerative cells in the mature cortex. Here, we synthesize the results from multiple rodent models of TBI, with a focus on cortical NG2-glia proliferation and lineage potential, and propose future avenues for glia researchers to address this unique cell type in TBI. As the molecular mechanisms that regulate NG2-glia regenerative potential are uncovered, we posit that future therapeutic strategies may exploit cortical NG2-glia to augment local cellular recovery following TBI.<p /> <p>Language: en</p>",
language="en",
issn="0894-1491",
doi="10.1002/glia.24342",
url="http://dx.doi.org/10.1002/glia.24342"
}