@article{ref1,
title="Predictors of treatment non-response for depression in a sample of female adolescents with risk-taking and self-injurious behavior - a one year follow-up",
journal="Journal of affective disorders",
year="2022",
author="Vöckel, Jasper and Sigrist, Christine and Kaess, Michael and Koenig, Julian",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: Depressive disorders (DD) are highly prevalent among adolescents. While up to 60 % do not respond to treatment, evidence on predictors of treatment non-response in this age group is mixed, impeding meaningful clinical implications. Drawing on a consecutive clinical cohort of adolescents with risk taking and self-injurious behavior, the present study aimed to identify predictors of treatment non-response for female DD in a naturalistic one year follow-up. <br><br>METHODS: The sample comprised female adolescents with verified DD (n = 152). Patients underwent assessments at baseline (T0) and follow-up (T1). Sociodemographic factors (e.g., age), clinical measures (e.g., symptom severity, trauma), and treatment variables (e.g. number of psychotherapy sessions), were analyzed as potential predictors of treatment non-response in unadjusted analyses and analyses adjusting for treatment intensity and age at baseline. Treatment response was defined based on not fulfilling formal diagnosis for DD at follow-up (52.3 %; n = 80) or the 50 % decrease in self-reported depressive symptoms (21.1 %; n = 32) from T0 to T1. <br><br>RESULTS: Greater depressive and overall symptom severity, greater frequency of self-injuries, history of suicide attempts and history of childhood trauma at T0 were robustly associated with treatment non-response based on diagnostic interviews. Only a lower number of siblings was robustly associated with treatment non-response based on self-reports. LIMITATIONS: Findings may not generalize to other treatment settings. <br><br>CONCLUSION: Collectively, our results highlight overall symptom severity as significant predictor of treatment non-response in female adolescents with depression. <br><br>METHODological differences (interviews versus self-reports) and potential implications from these findings for clinical practice are discussed.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2022.12.073",
url="http://dx.doi.org/10.1016/j.jad.2022.12.073"
}