@article{ref1,
title="A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma",
journal="Frontiers in human neuroscience",
year="2022",
author="Tymofiyeva, Olga and Hu, Rebecca and Kidambi, Roma and Nguyen, Ca and Max, Jeffrey E. and Yang, Tony T.",
volume="16",
number="",
pages="e1022791-e1022791",
abstract="INTRODUCTION: Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment (N = 379) and unexposed controls (N = 348). <br><br>METHODS: Anisotropic effect size-signed differential mapping (AES-SDM) was utilized to synthesize the studies. <br><br>RESULTS: We observed increased volume amongst adolescents with a history of childhood trauma in regions that are involved in motor functions and language production: left precentral gyrus, including part of the left inferior frontal gyrus, left fibers of the body of corpus callosum, and left postcentral gyrus. We observed decreased volume amongst adolescents with a history of childhood trauma in regions that are involved in language processing and/or sensory processing: bilateral cerebellum, bilateral middle temporal gyrus, left rostrum of corpus callosum, and bilateral supramarginal gyrus. <br><br>DISCUSSION: We suggest that these morphometric differences may be reflective of impaired motor development and increased sensory sensitivity and hypervigilance in adolescents with experiences of childhood trauma. Our results differ from meta-analytical findings in adults with history of childhood trauma and may contribute to a better understanding of neural mechanisms of childhood trauma, prediction of neurodevelopmental outcomes, and development of more effective and personalized therapies.<p /> <p>Language: en</p>",
language="en",
issn="1662-5161",
doi="10.3389/fnhum.2022.1022791",
url="http://dx.doi.org/10.3389/fnhum.2022.1022791"
}