@article{ref1,
title="Cortical thickness and curvature abnormalities in patients with major depressive disorder with childhood maltreatment: neural markers of vulnerability?",
journal="Asian journal of psychiatry",
year="2022",
author="Luo, Qianyi and Chen, Juran and Li, Yuhong and Lin, Xinyi and Yu, Huiwen and Lin, Xiaohui and Wu, Huawang and Peng, Hongjun",
volume="80",
number="",
pages="e103396-e103396",
abstract="BACKGROUND: Childhood maltreatment has been related to various disadvantageous lifetime outcomes. However, the brain structural alterations that occur in major depressive disorder (MDD) patients with childhood maltreatment are incompletely investigated. <br><br>METHODS: We extensively explored the cortical abnormalities including cortical volume, surface area, thickness, sulcal depth, and curvature in maltreated MDD patients. Twoway ANOVA was performed to distinguish the effects of childhood maltreatment and depression on structural abnormalities. Partial correlation analysis was performed to explore the relationship between childhood maltreatment and cortical abnormalities. Moreover, we plotted the receiver operating characteristic curve to examine whether the observed cortical abnormalities could be used as neuro biomarkers to identify maltreated MDD patients. <br><br>RESULTS: We reach the following findings: (i) relative to MDD without childhood maltreatment, MDD patients with childhood maltreatment existed increased cortical curvature in inferior frontal gyrus; (ii) compared to HC without childhood maltreatment, decreased cortical thickness was observed in anterior cingulate cortex and medial prefrontal cortex in MDD patients with childhood maltreatment; (iii) we confirmed the inseparable relationship between cortical curvature alterations in inferior frontal gyrus as well as childhood maltreatment; (iv) cortical curvature abnormality in inferior frontal gyrus could be applied as neural biomarker for clinical identification of MDD patients with childhood maltreatment. <br><br>CONCLUSIONS: Childhood maltreatment have a significant effects on cortical thickness and curvature abnormalities involved in inferior frontal gyrus, anterior cingulate cortex and medial prefrontal cortex, constituting the vulnerability to depression.<p /> <p>Language: en</p>",
language="en",
issn="1876-2018",
doi="10.1016/j.ajp.2022.103396",
url="http://dx.doi.org/10.1016/j.ajp.2022.103396"
}