@article{ref1,
title="Apathy in depression: an arterial spin labeling perfusion MRI study",
journal="Journal of psychiatric research",
year="2022",
author="Robert, G. and Gauvrit, J. Y. and Le Jeune, F. and Sauleau, P. and Vérin, M. and Guillery-Sollier, M. and Conan, C. and Combès, B. and Corouge, I. and Batail, J. M. and Drapier, D. and Ferre, J. C. and Barillot, C.",
volume="157",
number="",
pages="7-16",
abstract="INTRODUCTION: Apathy, as defined as a deficit in goal-directed behaviors, is a critical clinical dimension in depression associated with chronic impairment. Little is known about its cerebral perfusion specificities in depression. To explore neurovascular mechanisms underpinning apathy in depression by pseudo-continuous arterial spin labeling (pCASL) magnetic resonance imaging (MRI). <br><br>METHODS: Perfusion imaging analysis was performed on 90 depressed patients included in a prospective study between November 2014 and February 2017. Imaging data included anatomical 3D T1-weighted and perfusion pCASL sequences. A multiple regression analysis relating the quantified cerebral blood flow (CBF) in different regions of interest defined from the FreeSurfer atlas, to the Apathy Evaluation Scale (AES) total score was conducted. <br><br>RESULTS: After confound adjustment (demographics, disease and clinical characteristics) and correction for multiple comparisons, we observed a strong negative relationship between the CBF in the left anterior cingulate cortex (ACC) and the AES score (standardized beta = -0.74, corrected p value = 0.0008). <br><br>CONCLUSION: Our results emphasized the left ACC as a key region involved in apathy severity in a population of depressed participants. Perfusion correlates of apathy in depression evidenced in this study may contribute to characterize different phenotypes of depression.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2022.11.015",
url="http://dx.doi.org/10.1016/j.jpsychires.2022.11.015"
}