@article{ref1,
title="Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis",
journal="Molecular psychiatry",
year="2022",
author="Tielbeek, Jorim J. and Uffelmann, Emil and Williams, Benjamin S. and Colodro-Conde, Lucia and Gagnon, Éloi and Mallard, Travis T. and Levitt, Brandt E. and Jansen, Philip R. and Johansson, Ada and Sallis, Hannah M. and Pistis, Giorgio and Saunders, Gretchen R. B. and Allegrini, Andrea G. and Rimfeld, Kaili and Konte, Bettina and Klein, Marieke and Hartmann, Annette M. and Salvatore, Jessica E. and Nolte, Ilja M. and Demontis, Ditte and Malmberg, Anni L. K. and Burt, S. Alexandra and Savage, Jeanne E. and Sugden, Karen and Poulton, Richie and Harris, Kathleen Mullan and Vrieze, Scott and McGue, Matt and Iacono, William G. and Mota, Nina Roth and Mill, Jonathan and Viana, Joana F. and Mitchell, Brittany L. and Morosoli, José J. and Andlauer, Till F. M. and Ouellet-Morin, Isabelle and Tremblay, Richard E. and Côté, Sylvana M. and Gouin, Jean-Philippe and Brendgen, Mara R. and Dionne, Ginette and Vitaro, Frank and Lupton, Michelle K. and Martin, Nicholas G. and Castelao, Enrique and Räikkönen, Katri and Eriksson, Johan G. and Lahti, Jari and Hartman, Catharina A. and Oldehinkel, Albertine J. and Snieder, Harold and Liu, Hexuan and Preisig, Martin and Whipp, Alyce and Vuoksimaa, Eero and Lu, Yi and Jern, Patrick and Rujescu, Dan and Giegling, Ina and Palviainen, Teemu and Kaprio, Jaakko and Harden, Kathryn Paige and Munafò, Marcus R. and Morneau-Vaillancourt, Genevieve and Plomin, Robert and Viding, Essi and Boutwell, Brian B. and Aliev, Fazil and Dick, Danielle M. and Popma, Arne and Faraone, Stephen V. and Børglum, Anders D. and Medland, Sarah E. and Franke, Barbara and Boivin, Michel and Pingault, Jean-Baptiste and Glennon, Jeffrey C. and Barnes, J. C. and Fisher, Simon E. and Moffitt, Terrie E. and Caspi, Avshalom and Polderman, Tinca J. C. and Posthuma, Danielle",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Consortium (BroadABC) meta-analyzed data from 28 discovery samples (N = 85,359) and five independent replication samples (N = 8058) with genotypic data and broad measures of ASB. We identified the first significant genetic associations with broad ASB, involving common intronic variants in the forkhead box protein P2 (FOXP2) gene (lead SNP rs12536335, p = 6.32 × 10(-10)). Furthermore, we observed intronic variation in Foxp2 and one of its targets (Cntnap2) distinguishing a mouse model of pathological aggression (BALB/cJ strain) from controls (BALB/cByJ strain). Polygenic risk score (PRS) analyses in independent samples revealed that the genetic risk for ASB was associated with several antisocial outcomes across the lifespan, including diagnosis of conduct disorder, official criminal convictions, and trajectories of antisocial development. We found substantial genetic correlations of ASB with mental health (depression r(g) = 0.63, insomnia r(g) = 0.47), physical health (overweight r(g) = 0.19, waist-to-hip ratio r(g) = 0.32), smoking (r(g) = 0.54), cognitive ability (intelligence r(g) = -0.40), educational attainment (years of schooling r(g) = -0.46) and reproductive traits (age at first birth r(g) = -0.58, father's age at death r(g) = -0.54). Our findings provide a starting point toward identifying critical biosocial risk mechanisms for the development of ASB.<p /> <p>Language: en</p>",
language="en",
issn="1359-4184",
doi="10.1038/s41380-022-01793-3",
url="http://dx.doi.org/10.1038/s41380-022-01793-3"
}