@article{ref1,
title="Depression and suicide risk in mild cognitive impairment: the role of Alzheimer's disease biomarkers",
journal="Psicothema",
year="2022",
author="Ferrer-Cairols, Inés and Montoliu, Teresa and Crespo-Sanmiguel, Isabel and Pulopulos, Matias M. and Hidalgo, Vanesa and Gómez, Enriqueta and López-Cuevas, Rogelio and Cuevas, Ana and Martín, Nuria and Baquero, Miguel and Salvador, Alicia",
volume="34",
number="4",
pages="553-561",
abstract="BACKGROUND: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer’s Disease (AD) could help to clarify the role of depression and SI in AD. <br><br>METHOD: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-ß (Aß), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed. <br><br>RESULTS: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide. <br><br>CONCLUSIONS: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms.<p /> <p>Language: en</p>",
language="en",
issn="0214-9915",
doi="10.7334/psicothema2022.103",
url="http://dx.doi.org/10.7334/psicothema2022.103"
}