@article{ref1,
title="The toxicokinetics of acute paraquat poisoning in specific patients: a case series",
journal="Journal of international medical research",
year="2022",
author="Shi, Longke and Yu, Guangcai and Li, Yaqian and Zhao, Liwen and Wen, Zixin and Tao, Yiming and Wang, Wenjun and Jian, Xiangdong",
volume="50",
number="9",
pages="e3000605221122745-e3000605221122745",
abstract="Paraquat is a non-selective contact herbicide that is absorbed through the digestive tract and skin and can cause multiple organ damage. The toxicokinetics of paraquat poisoning in specific patients are rarely reported. Case 1 was a 76-year-old man who intermittently immersed his perineum in diluted paraquat solution for 3 consecutive days because of eczema of the perineal skin. On admission, the patient's scrotal skin was severely corroded and his blood paraquat concentration was 0.5 μg/mL. He developed severe kidney and lung damage after admission and died on Day 6 of admission. Case 2 was a 23-year-old woman who ingested paraquat during gestational week 36. Her initial blood paraquat concentration was 0.81 μg/mL. The patient refused hemoperfusion and a cesarean section. She birthed a baby girl 83 hours after ingesting paraquat. Paraquat concentrations in postnatal maternal blood, fetal blood, umbilical cord blood, and amniotic fluid were 0.19 μg/mL, 0.23 μg/mL, 0.20 μg/mL, and 0.47 μg/mL, respectively. The baby died within hours of birth and the mother died of refractory respiratory failure 2 days after delivery. This paper provides clues about paraquat toxicokinetics in specific patient types and indicates that paraquat can be absorbed through the scrotal skin and the placental barrier.<p /> <p>Language: en</p>",
language="en",
issn="0300-0605",
doi="10.1177/03000605221122745",
url="http://dx.doi.org/10.1177/03000605221122745"
}