@article{ref1,
title="Acute methanol poisoning with bilateral diffuse cerebral hemorrhage: a case report",
journal="World journal of clinical cases",
year="2022",
author="Li, Jin and Feng, Zhi-Juan and Liu, Lei and Ma, Yu-Jie",
volume="10",
number="19",
pages="6571-6579",
abstract="BACKGROUND: Acute methanol poisoning (AMP) is a systemic disease that mainly affects the central nervous system and is characterized by ocular damage and metabolic acidosis. If appropriate treatments are inadequate or delayed, the mortality can exceed 40%. As the most serious complication, cerebral hemorrhage is rare with reported prevalence of 7%-19%. CASE SUMMARY: A 62-year-old man drank liquor mixed with 45% methanol and 35% alcohol. His vision blurred 10 h later and he fell into coma in another 9 h. Serum toxicological tests were performed immediately, and continuous renal replacement therapy (CRRT) was carried out as the lactic acid exceeded 15 mmol/L and blood pH was 6.78. In addition, the toxicological report revealed 1300.5 μg/mL of methanol in serum and 1500.2 μg/mL in urine. After 59 h of CRRT, the methanol level decreased to 126.0 μg/mL in serum and 151.0 μg/mL in urine. However, the patient was still unconscious and his pupillary light reflex was slow. Computed tomography showed hemorrhage in the left putamen. After 16 d of life support treatment, putamen hemorrhage developed into diffuse symmetric intracerebral hemorrhage. In the end, his family gave up and the patient was discharged, and died in a local hospital. <br><br>CONCLUSION: Cerebral hemorrhage requires constant vigilance during the full course of treatment for severe cases of AMP.<p /> <p>Language: en</p>",
language="en",
issn="2307-8960",
doi="10.12998/wjcc.v10.i19.6571",
url="http://dx.doi.org/10.12998/wjcc.v10.i19.6571"
}