@article{ref1,
title="Health care utilization and outcomes in older adults after traumatic brain injury: a CENTER-TBI study",
journal="Injury",
year="2022",
author="van der Vlegel, Marjolein and Mikolić, Ana and Lee Hee, Quentin and Kaplan, Z. L. Rana and Retel Helmrich, Isabel R. A. and van Veen, Ernest and Andelic, Nada and Steinbuechel, Nicole V. and Plass, Anne Marie and Zeldovich, Marina and Wilson, Lindsay and Maas, Andrew I. R. and Haagsma, Juanita A. and Polinder, Suzanne and Åkerlund, Cecilia and George, Pradeep and Lanyon, Linda and Muraleedharan, Visakh and Nelson, David and Amrein, Krisztina and Ezer, Erzsebet and Kovacs, Noemi and Melegh, Bela and Nyirádi, József and Tamas, Viktoria and Vámos, Zoltán and Sorinola, Abayomi and Andelic, Nada and Andreassen, Lasse and Anke, Audny and Frisvold, Shirin and Antoni, Anna and Schwendenwein, Elisabeth and Audibert, Gérard and Azouvi, Philippe and Azzolini, Maria Luisa and Beretta, Luigi and Calvi, Maria Rosa and Bartels, Ronald and Boogert, Hugo den and Barzo, Pal and Beauvais, Romuald and Perera, Natascha and Beer, Ronny and Helbok, Raimund and Bellander, Bo-Michael and Belli, Antonio and Benali, Habib and Degos, Vincent and Galanaud, Damien and Perlbarg, Vincent and Berardino, Maurizio and Cavallo, Simona and Blaabjerg, Morten and Rosenlund, Christina and Schou, Rico Frederik and Bragge, Peter and Brazinova, Alexandra and Majdan, Marek and Taylor, Mark Steven and Zelinkova, Veronika and Brinck, Vibeke and Jarrett, Mike and Brooker, Joanne and Donoghue, Emma and Synnot, Anneliese and Brorsson, Camilla and Koskinen, Lars-Owe and Sundström, Nina and Büki, Andras and Czeiter, Endre and Bullinger, Monika and Cabeleira, Manuel and Czosnyka, Marek and Dixit, Abhishek and Ercole, Ari and Koraropoulos, Evgenios and Menon, David and Newcombe, Virginia and Richter, Sophie and Smielewski, Peter and Stamatakis, Emmanuel and Williams, Guy and Winzeck, Stefan and Zeiler, Frederick A. and Caccioppola, Alessio and Calappi, Emiliana and Carbonara, Marco and Ortolano, Fabrizio and Zoerle, Tommaso and Stocchetti, Nino and Cameron, Peter and Gantner, Dashiell and Murray, Lynnette and Trapani, Tony and Vallance, Shirley and Lozano, Guillermo Carbayo and Pomposo, Inigo and Castaño-Leon, Ana M. and Gómez, Pedro A. and Lagares, Alfonso and Chevallard, Giorgio and Chieregato, Arturo and Citerio, Giuseppe and Vargiolu, Alessia and Ceyisakar, Iris and Gravesteijn, Benjamin and Haagsma, Juanita A. and Huijben, Jilske and Lingsma, Hester and Nieboer, Daan and Mikolić, Ana and Polinder, Suzanne and Sewalt, Charlie and Steyerberg, Ewout W. and Velt, Kimberley and Voormolen, Daphne and Wiegers, Eveline and Peul, Wilco and van Dijck, Jeroen T. J. M. and van Essen, Thomas A. and van Wijk, Roel P. J. and Clusmann, Hans and Coburn, Mark and Kowark, Ana and Rossaint, Rolf and Coles, Jonathan and Cooper, Jamie D. and Correia, Marta and Čovid, Amra and von Steinbüchel, Nicole and Curry, Nicola and Stanworth, Simon and Dahyot-Fizelier, Claire and Dark, Paul and Johnson, Faye and Dawes, Helen and Esser, Patrick and van Heugten, Caroline and De Keyser, Véronique and Maas, Andrew I. R. and Menovsky, Tomas and Van der Steen, Gregory and Corte, Francesco Della and Grossi, Francesca and Depreitere, Bart and Đilvesi, Đula and Golubovic, Jagos and Karan, Mladen and Vuleković, Petar and Dreier, Jens and Vajkoczy, Peter and Wolf, Stefan and Dulière, Guy-Loup and Maréchal, Hugues and Fabricius, Martin and Kondziella, Daniel and Feigin, Valery L. and Jones, Kelly and Ao, Braden Te and Theadom, Alice and Foks, Kelly and Haitsma, Iain and Volovici, Victor and Furmanov, Alex and Rosenthal, Guy and Gagliardo, Pablo and Gao, Guoyi and Jiang, Ji-Yao and Ghuysen, Alexandre and Giga, Lelde and Valeinis, Egils and Ziverte, Agate and Glocker, Ben and Rueckert, Daniel and Gratz, Johannes and Gruen, Russell L. and Gupta, Deepak and Roe, Cecilie and Helseth, Eirik and Roise, Olav and Horton, Lindsay and Wilson, Lindsay and Hutchinson, Peter J. and Kolias, Angelos G. and Jacobs, Bram and van der Naalt, Joukje and Jankowski, Stefan and Kompanje, Erwin and Timmers, Marjolein and Laureys, Steven and Ledoux, Didier and Misset, Benoit and Lecky, Fiona and Olubukola, Otesile and Lefering, Rolf and Schäfer, Nadine and Legrand, Valerie and Lejeune, Aurelie and Vega, Emmanuel and Mattern, Julia and Levi, Leon and Lightfoot, Roger and Maegele, Marc and Manara, Alex and Thomas, Matt and Manley, Geoffrey and Martino, Costanza and Sakowitz, Oliver and Sanchez-Porras, Renan and Younsi, Alexander and McMahon, Catherine and Negru, Ancuta and Orešič, Matej and Palotie, Aarno and Parizel, Paul M. and Payen, Jean-François and Persona, Paolo and Piippo-Karjalainen, Anna and Pirinen, Matti and Ples, Horia and Posti, Jussi P. and Puybasset, Louis and Rădoi, Andreea and Ragauskas, Arminas and Raj, Rahul and Rambadagalla, Malinka and Rhodes, Jonathan and Richardson, Sylvia and Ripatti, Samuli and Ročka, Saulius and Rosand, Jonathan and Rosenfeld, Jeffrey V. and Rossi, Sandra and Rusnak, Martin and Sahuquillo, Juan and Sandor, Janos and Schmidt, Silke and Schoechl, Herbert and Schoonman, Guus and Skandsen, Toril and Stevens, Robert and Stewart, William and Takala, Riikka and Tamosuitis, Tomas and Tenovuo, Olli and Tibboel, Dick and Tolias, Christos and Tudora, Cristina Maria and van der Jagt, Mathieu and Van Hecke, Wim and Van Praag, Dominique and Vyvere, Thijs Vande and Verheyden, Jan and Vespa, Paul M. and Vik, Anne and Vilcinis, Rimantas and Wang, Kevin K. W. and Yang, Zhihui and Ylen, Peter",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. <br><br>METHODS: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. <br><br>RESULTS: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. <br><br>CONCLUSION: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.<p /> <p>Language: en</p>",
language="en",
issn="0020-1383",
doi="10.1016/j.injury.2022.05.009",
url="http://dx.doi.org/10.1016/j.injury.2022.05.009"
}