@article{ref1,
title="Threat vigilance and intrinsic amygdala connectivity",
journal="Human brain mapping",
year="2022",
author="Kirk, Peter A. and Holmes, Avram J. and Robinson, Oliver J.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="A well-documented amygdala-dorsomedial prefrontal circuit is theorized to promote attention to threat (&quot;threat vigilance&quot;). Prior research has implicated a relationship between individual differences in trait anxiety/vigilance, engagement of this circuitry, and anxiogenic features of the environment (e.g., through threat-of-shock and movie-watching). In the present study, we predicted that-for those scoring high in self-reported anxiety and a behavioral measure of threat vigilance-this circuitry is chronically engaged, even in the absence of anxiogenic stimuli. Our analyses of resting-state fMRI data (N = 639) did not, however, provide evidence for such a relationship. Nevertheless, in our planned exploratory analyses, we saw a relationship between threat vigilance behavior (but not self-reported anxiety) and intrinsic amygdala-periaqueductal gray connectivity. Here, we suggest this subcortical circuitry may be chronically engaged in hypervigilant individuals, but that amygdala-prefrontal circuitry may only be engaged in response to anxiogenic stimuli.<p /> <p>Language: en</p>",
language="en",
issn="1065-9471",
doi="10.1002/hbm.25851",
url="http://dx.doi.org/10.1002/hbm.25851"
}