@article{ref1,
title="Traumatic brain injury and early onset dementia in post 9-11 veterans",
journal="Brain injury",
year="2022",
author="Kennedy, Eamonn and Panahi, Samin and Stewart, Ian J. and Tate, David F. and Wilde, Elisabeth A. and Kenney, Kimbra and Werner, J. Kent and Gill, Jessica and Diaz-Arrastia, Ramon and Amuan, Megan and Van Cott, Anne C. and Pugh, Mary Jo",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVES: To assess traumatic brain injury (TBI)-related risks factors for early-onset dementia (EOD). <br><br>BACKGROUND: Younger Post-9/11 Veterans may be at elevated risk for EOD due to high rates of TBI in early/mid adulthood. Few studies have explored the longitudinal relationship between traumatic brain injury (TBI) and the emergence of EOD subtypes. <br><br>METHODS: This matched case-control study used data from the Veterans Health Administration (VHA) to identify Veterans with EOD. To address the low positive predictive value (PPV = 0.27) of dementia algorithms in VHA records, primary outcomes were Alzheimer's disease (AD) and frontotemporal dementia (FTD). Logistic regression identified conditions associated with dementia subtypes. <br><br>RESULTS: The EOD cohort included Veterans with AD (n = 689) and FTD (n = 284). There were no significant demographic differences between the EOD cohort and their matched controls. After adjustment, EOD was significantly associated with history of TBI (OR: 3.05, 2.42-3.83), epilepsy (OR: 4.8, 3.3-6.97), other neurological conditions (OR: 2.0, 1.35-2.97), depression (OR: 1.35, 1.12-1.63) and cardiac disease (OR: 1.36, 1.1-1.67). <br><br>CONCLUSION: Post-9/11 Veterans have higher odds of EOD following TBI. A sensitivity analysis across TBI severity confirmed this trend, indicating that the odds for both AD and FTD increased after more severe TBIs.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2022.2033846",
url="http://dx.doi.org/10.1080/02699052.2022.2033846"
}