@article{ref1,
title="Trajectories of treatment response and non-response in youth at high risk for suicide",
journal="Journal of the American Academy of Child and Adolescent Psychiatry",
year="2022",
author="Berk, Michele S. and Gallop, Robert and Asarnow, Joan R. and Adrian, Molly and Avina, Claudia and Hughes, Jennifer L. and Korslund, Kathryn E. and McCauley, Elizabeth",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: To examine trajectories of treatment response in suicidal youth who participated in a randomized controlled trial (RCT) comparing dialectical behavior therapy (DBT) and individual and group supportive therapy (IGST). <br><br>METHOD: Using latent class analysis across both treatment conditions, we conducted secondary analyses of data from a multisite RCT with N = 173 youth, ages 12-18, with repetitive self-harm (SH, including > 1 lifetime suicide attempt) and elevated suicidal ideation (SI). The sample was 95% female, 56.4% White and 27.49% Latina. Participants received 6 months of DBT or IGST and 6 months of follow-up. Primary outcomes were SH and SI. <br><br>RESULTS: 63% of the sample were members of latent classes that showed improvement in SI and 74% showed improvement in SH. 13% were &quot;total non-responders,&quot; with no improvement in SI or SH. SH non-response emerged at the mid-point of treatment (3 months), with non-responders showing a sharp increase in SH over the remainder of treatment and follow-up. Youth in DBT were significantly more likely to be an SH responder v. non-responder than those in IGST (ꭓ(2) [1] =6.53, p=0.01). An optimal threshold cut point using multivariate predictors of total non-response (White, externalizing symptoms, total SH, and SI) predicted total non-responders to DBT with 100% accuracy. <br><br>CONCLUSION: This is the first study to identify trajectories of both SI and SH response to treatment in a sample of adolescents at risk of suicide. <br><br>RESULTS may inform personalized treatment approaches.<p /> <p>Language: en</p>",
language="en",
issn="0890-8567",
doi="10.1016/j.jaac.2022.01.010",
url="http://dx.doi.org/10.1016/j.jaac.2022.01.010"
}