@article{ref1,
title="A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort",
journal="Journal of psychiatric research",
year="2022",
author="Li, Chun'e and Liang, Xiao and Cheng, Shiqiang and Wen, Yan and Pan, Chuyu and Zhang, Huijie and Chen, Yujing and Zhang, Jingxi and Zhang, Zhen and Yang, Xuena and Meng, Peilin and Zhang, Feng",
volume="147",
number="",
pages="59-66",
abstract="The effects of gene-by-environment (G×E) interactions on complex diseases are significant, especially the superimposed effects of multiple environmental factors. However, research on the multi-environments-gene interactions of anxiety, depression, and self-harm is still limited. This study included white individuals (N = 66,041-74,482) from the UK Biobank. We fitted all environmental factors to a single environmental score (ES), and the estimated ES was used to calculate the multiplicative interaction effects between ES and genome-wide SNPs. Heritability was stratified by minor allele frequency (MAF) and linkage disequilibrium (LD). Our research found 10 loci with significant interaction effects, such as rs114830993 (PRICKLE2, P = 2.30 × 10(-8)), rs151323364 (ASTN2, P = 2.71 × 10(-10)) and rs536631793 (SYN3, P = 4.09 × 10(-8)). In addition, we found that G×E heritability has a significant contribution to the depression of Patient Health Questionnaire-9 (PHQ-9) scores (h(2)(G×E (female)) = 6.1%, h(2)(G×E (male)) = 8.7%). Our research supported the important influence of multi-environments-gene interactions on anxiety, depression, and self-harm and provided clues for the prevention and etiological research of them.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2022.01.009",
url="http://dx.doi.org/10.1016/j.jpsychires.2022.01.009"
}