@article{ref1,
title="Osteosarcopenia synergistically increases the risk of falls in patients with rheumatoid arthritis",
journal="Osteoporos and Sarcopenia",
year="2021",
author="Tada, Masahiro and Yamada, Yutaro and Mandai, Koji and Matsumoto, Yoshinari and Hidaka, Noriaki",
volume="7",
number="4",
pages="140-145",
abstract="OBJECTIVES: Osteosarcopenia is defined as osteoporosis with sarcopenia. The impacts of osteosarcopenia on falls and fractures in rheumatoid arthritis (RA) patients were investigated using 4 years of data from a longitudinal study (CHIKARA study). <br><br>METHODS: The patients were divided into 4 groups by their baseline status: no sarcopenia and no osteoporosis (SP-OP-); only sarcopenia (SP + OP-); only osteoporosis (SP-OP+); and both sarcopenia and osteoporosis (SP + OP+). Survival rates and Cox hazard ratios were analyzed using falls and fractures as endpoints, adjusted by age, sex, and body mass index. <br><br>RESULTS: A total of 100 RA patients (SP-OP-: 44%, SP + OP-: 17%, SP-OP+: 28%, and SP + OP+: 11%) were enrolled; 37 patients had falls, and 19 patients had fractures. The fall-free and fracture-free survival rates were significantly lower in SP + OP+ (36.4%, 54.5%) than in SP-OP- (75.0%, 86.4%). The hazard ratio of falls was significantly increased in SP + OP+, by 3.32-fold (95%CI: 1.01-10.9), whereas in SP + OP- and SP-OP+, there were no differences compared to SP-OP-. <br><br>CONCLUSIONS: The survival rates with the endpoints of falls and fractures in RA patients with osteosarcopenia were lower during 4-year follow-up. The risk of falls increased with the synergistic effect of osteoporosis and sarcopenia.<p /> <p>Language: en</p>",
language="en",
issn="2405-5255",
doi="10.1016/j.afos.2021.11.002",
url="http://dx.doi.org/10.1016/j.afos.2021.11.002"
}