@article{ref1,
title="Ciguatera poisoning",
journal="Practical neurology",
year="2007",
author="Achaibar, Kira C. and Moore, S. and Bain, Peter G.",
volume="7",
number="5",
pages="316-322",
abstract="Ciguatera is a form of poisoning that occurs after eating tropical and subtropical ciguatoxic fish. The ciguatoxins are a family of heat stable, lipid soluble cyclic polyether compounds that bind to and open voltage-sensitive Na(+) channels at resting membrane potential, resulting in neural hyperexcitability, as well as swelling of the nodes of Ranvier. The authors describe a 45-year-old man who developed acute gastrointestinal symptoms in Antigua soon after eating red snapper and grouper, potentially &quot;ciguatoxic fish&quot;. This was followed by neurological symptoms 24-48 hours later, including temperature reversal (paradoxical dysaesthesia), intense pruritus and increased nociception as a result of a small fibre peripheral neuropathy. The patient's symptoms and small fibre neuropathy improved over a period of 10 months.<p /> <p>Language: en</p>",
language="en",
issn="1474-7758",
doi="10.1136/jnnp.2007.129049",
url="http://dx.doi.org/10.1136/jnnp.2007.129049"
}