@article{ref1,
title="Recent applications of phosphodiesterase (PDE5) inhibition assays for detecting adulterated sexual enhancement products",
journal="Drug testing and analysis",
year="2021",
author="Santillo, Michael F.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Consumer products marketed for sexual enhancement are frequently adulterated with erectile dysfunction (ED) drugs and analogs; consuming these undisclosed adulterants can pose significant health hazards. Although ED drugs/analogs have unpredictable and diverse structures that pose challenges for detecting them, they all share the ability to inhibit phosphodiesterase-5 (PDE5) activity, a pharmacological mechanism responsible for their effects. Consequently, several PDE5 inhibition assays have been recently applied as screening methods to detect ED drug/analogs in products. Here, the successes and challenges are highlighted for screening sexual enhancement products by PDE5 inhibition assays.<p /> <p>Language: en</p>",
language="en",
issn="1942-7603",
doi="10.1002/dta.3209",
url="http://dx.doi.org/10.1002/dta.3209"
}