@article{ref1,
title="Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors",
journal="Biological psychiatry",
year="2021",
author="Mullins, Niamh and Kang, JooEun and Campos, Adrian I. and Coleman, Jonathan R. I. and Edwards, Alexis C. and Galfalvy, Hanga and Levey, Daniel F. and Lori, Adriana and Shabalin, Andrey and Starnawska, Anna and Su, Mei-Hsin and Watson, Hunna J. and Adams, Mark and Awasthi, Swapnil and Gandal, Michael and Hafferty, Jonathan D. and Hishimoto, Akitoyo and Kim, Minsoo and Okazaki, Satoshi and Otsuka, Ikuo and Ripke, Stephan and Ware, Erin B. and Bergen, Andrew W. and Berrettini, Wade H. and Bohus, Martin and Brandt, Harry and Chang, Xiao and Chen, Wei J. and Chen, Hsi-Chung and Crawford, Steven and Crow, Scott and DiBlasi, Emily and Duriez, Philibert and Fernández-Aranda, Fernando and Fichter, Manfred M. and Gallinger, Steven and Glatt, Stephen J. and Gorwood, Philip and Guo, Yiran and Hakonarson, Hakon and Halmi, Katherine A. and Hwu, Hai-Gwo and Jain, Sonia and Jamain, Stéphane and Jimenez-Murcia, Susana and Johnson, Craig and Kaplan, Allan S. and Kaye, Walter H. and Keel, Pamela K. and Kennedy, James L. and Klump, Kelly L. and Li, Dong and Liao, Shih-Cheng and Lieb, Klaus and Lilenfeld, Lisa and Liu, Chih-Min and Magistretti, Pierre J. and Marshall, Christian R. and Mitchell, James E. and Monson, Eric T. and Myers, Richard M. and Pinto, Dalila and Powers, Abigail and Ramoz, Nicolas and Roepke, Stefan and Rozanov, Vsevolod A. and Scherer, Stephen W. and Schmahl, Christian and Sokolowski, Marcus and Strober, Michael and Thornton, Laura M. and Treasure, Janet and Tsuang, Ming T. and Witt, Stephanie H. and Woodside, D. Blake and Yilmaz, Zeynep and Zillich, Lea and Adolfsson, Rolf and Agartz, Ingrid and Air, Tracy M. and Alda, Martin and Alfredsson, Lars and Andreassen, Ole A. and Anjorin, Adebayo and Appadurai, Vivek and Soler Artigas, María and Van der Auwera, Sandra and Azevedo, M. Helena and Bass, Nicholas and Bau, Claiton H. D. and Baune, Bernhard T. and Bellivier, Frank and Berger, Klaus and Biernacka, Joanna M. and Bigdeli, Tim B. and Binder, Elisabeth B. and Boehnke, Michael and Boks, Marco P. M. and Bosch, Rosa and Braff, David L. and Bryant, Richard and Budde, Monika and Byrne, Enda M. and Cahn, Wiepke and Casas, Miguel and Castelao, Enrique and Cervilla, Jorge A. and Chaumette, Boris and Cichon, Sven and Corvin, Aiden and Craddock, Nicholas and Craig, David and Degenhardt, Franziska and Djurovic, Srdjan and Edenberg, Howard J. and Fanous, Ayman H. and Foo, Jerome C. and Forstner, Andreas J. and Frye, Mark and Fullerton, Janice M. and Gatt, Justine M. and Gejman, Pablo V. and Giegling, Ina and Grabe, Hans J. and Green, Melissa J. and Grevet, Eugenio H. and Grigoroiu-Serbanescu, Maria and Gutiérrez, Blanca and Guzman-Parra, Jose and Hamilton, Steven P. and Hamshere, Marian L. and Hartmann, Annette and Hauser, Joanna and Heilmann-Heimbach, Stefanie and Hoffmann, Per and Ising, Marcus and Jones, Ian and Jones, Lisa A. and Jonsson, Lina and Kahn, Rene S. and Kelsoe, John R. and Kendler, Kenneth S. and Kloiber, Stefan and Koenen, Karestan C. and Kogevinas, Manolis and Konte, Bettina and Krebs, Marie-Odile and Landén, Mikael and Lawrence, Jacob and Leboyer, Marion and Lee, Phil H. and Levinson, Douglas F. and Liao, Calwing and Lissowska, Jolanta and Lucae, Susanne and Mayoral, Fermín and McElroy, Susan L. and McGrath, Patrick and McGuffin, Peter and McQuillin, Andrew and Medland, Sarah E. and Mehta, Divya and Melle, Ingrid and Milaneschi, Yuri and Mitchell, Philip B. and Molina, Esther and Morken, Gunnar and Mortensen, Preben Bo and Müller-Myhsok, Bertram and Nievergelt, Caroline and Nimgaonkar, Vishwajit and Nothen, Markus M. and O'Donovan, Michael C. and Ophoff, Roel A. and Owen, Michael J. and Pato, Carlos and Pato, Michele T. and Penninx, Brenda W. J. H. and Pimm, Jonathan and Pistis, Giorgio and Potash, James B. and Power, Robert A. and Preisig, Martin and Quested, Digby and Ramos-Quiroga, Josep Antoni and Reif, Andreas and Ribasés, Marta and Richarte, Vanesa and Rietschel, Marcella and Rivera, Margarita and Roberts, Andrea and Roberts, Gloria and Rouleau, Guy A. and Rovaris, Diego Luiz and Rujescu, Dan and Sánchez-Mora, Cristina and Sanders, Alan R. and Schofield, Peter R. and Schulze, Thomas G. and Scott, Laura J. and Serretti, Alessandro and Shi, Jianxin and Shyn, Stanley I. and Sirignano, Lea and Sklar, Pamela and Smeland, Olav B. and Smoller, Jordan W. and Sonuga-Barke, Edmund J. S. and Spalletta, Gianfranco and Strauss, John S. and Świątkowska, Beata and Trzaskowski, Maciej and Turecki, Gustavo and Vilar-Ribó, Laura and Vincent, John B. and Völzke, Henry and Walters, James T. R. and Shannon Weickert, Cynthia and Weickert, Thomas W. and Weissman, Myrna M. and Williams, Leanne M. and Wray, Naomi R. and Zai, Clement C. and Ashley-Koch, Allison E. and Beckham, Jean C. and Hauser, Elizabeth R. and Hauser, Michael A. and Kimbrel, Nathan A. and Lindquist, Jennifer H. and McMahon, Benjamin and Oslin, David W. and Qin, Xuejun and Agerbo, Esben and Børglum, Anders D. and Breen, Gerome and Erlangsen, Annette and Esko, Tõnu and Gelernter, Joel and Hougaard, David M. and Kessler, Ronald C. and Kranzler, Henry R. and Li, Qingqin S. and Martin, Nicholas G. and McIntosh, Andrew M. and Mors, Ole and Nordentoft, Merete and Olsen, Catherine M. and Porteous, David and Ursano, Robert J. and Wasserman, Danuta and Werge, Thomas and Whiteman, David C. and Bulik, Cynthia M. and Coon, Hilary and Demontis, Ditte and Docherty, Anna R. and Kuo, Po-Hsiu and Lewis, Cathryn M. and Mann, J. John and Renteria, Miguel E. and Smith, Daniel J. and Stahl, Eli A. and Stein, Murray B. and Streit, Fabian and Willour, Virginia and Ruderfer, Douglas M.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. <br><br>METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. <br><br>RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. <br><br>CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.<p /> <p>Language: en</p>",
language="en",
issn="0006-3223",
doi="10.1016/j.biopsych.2021.05.029",
url="http://dx.doi.org/10.1016/j.biopsych.2021.05.029"
}