@article{ref1,
title="Pro-inflammatory cytokines and suicidal behavior among patients with bipolar I disorder",
journal="Journal of psychiatric research",
year="2021",
author="Huang, Mao-Hsuan and Chen, Mu-Hong and Chan, Yee-Lam E. and Li, Cheng-Ta and Tsai, Shih-Jen and Bai, Ya-Mei and Su, Tung-Ping",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: Suicidal behavior and different mood states of bipolar I disorder (BD) have been shown to be associated with dysregulated proinflammatory cytokines. Only a few studies have examined the association between inflammation and SB in BD, and the association between proinflammatory cytokines, SB, and cognitive deficits in patients with BD remains unclear.
METHODS: 77 patients with BD and 61 age-/sex-matched healthy controls were recruited. Patients were divided into two groups: with suicidal ideation (SI; n = 21) and no SI (n = 56). SI was defined by a score of ≥1 in item 10 of Montgomery Åsberg Depression Rating Scale. Levels of proinflammatory cytokines, including soluble interleukin-6 receptor (sIL-6R), soluble tumor necrosis factor-α receptor type 1 (sTNF-αR1), and C-reactive protein (CRP), were measured, and cognitive function was assessed using 2-back task and Go/No-Go task.
RESULTS: Patients with SI had higher levels of sTNF-αR1 than those without SI and the controls (p = .004). BD patients with or without a history of suicide attempt had higher levels of CRP than the controls. SI was associated with serum levels of sTNF-αR1 and IL-6sR, even after additionally controlling for working memory and inhibitory control (p < .05).
CONCLUSION: This study indicates that serum levels of sTNF-αR1 have distinct differences between BD patients with or without SI, and our findings strengthen the hypothesis of a link between suicidal behavior and neuro-inflammation pathophysiology in BD. Language: en
",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2021.11.030",
url="http://dx.doi.org/10.1016/j.jpsychires.2021.11.030"
}