@article{ref1,
title="Sulfur mustard and biological ageing: a multisystem biological health score approach as an extension of the allostatic load in sardasht chemical veterans",
journal="International immunopharmacology",
year="2021",
author="Nasiri, Leila and Vaez-Mahdavi, Mohammad-Reza and Hassanpour, Hossein and Kaboudanian Ardestani, Sussan and Askari, Nayere",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Mustard gas as a chemical weapon has been used in wars and its long-term side effects are substantial in the human body. This study was aimed to apply an extension of allostatic load, known as synthetic biological health score (BHS), including the wear-and-tear of four physiological systems (endocrine, inflammatory, cardiovascular and metabolic systems) and two organs (liver and kidney) to estimate biological aging caused by sulfur mustard (SM) gas poisoning. <br><br>METHODS: The plasma samples were prepared from two following groups of people; 1) 446 individuals exposed to SM gas in 1987. 2) 115 healthy members, at the same range of age and residence, as the non-exposed group. These people were chosen from the same patients' families and have not had any exposure to SM or pulmonary dysfunction. To estimate BHS, 18 blood-derived biomarkers of the mentioned systems and organs were measured and the relative contribution of many social and body parameters across the age groups was explored. <br><br>RESULTS: It was revealed, in BHS calculation, the cardiovascular system had the most effect. Also, in the SM group, BHS was significantly higher than in the control group. This feature has a positive correlation with physical parameter (BMI) and a negative correlation with social parameters (salary and educational levels). <br><br>CONCLUSION: The multisystem BHS could be useful in the evaluation of biological aging due to SM exposure. Social (education, good-paying job) and physical (BMI) parameters could influence BHS and the higher BHS indicates the progress of biological aging due to mustard gas.<p /> <p>Language: en</p>",
language="en",
issn="1567-5769",
doi="10.1016/j.intimp.2021.108375",
url="http://dx.doi.org/10.1016/j.intimp.2021.108375"
}